| ORIGINAL ARTICLE |
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| Year : 2021 | Volume
: 19
| Issue : 1 | Page : 32-37 |
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An evaluation of the effectiveness of preemptive ketamine for postoperative analgesia in elective thyroidectomy
Joshua Olayinka Oni1, Benjamin Olusomi Bolaji2, Israel Kayode Kolawole2, Olufemi Adebayo Ige2, Olanrewaju Olubukola Oyedepo2, Majeed Babajide Adegboye2
1 Department of Anaesthesia, University of Ilorin Teaching Hospital, Ilorin, Nigeria
2 Department of Anaesthesia, University of Ilorin, Ilorin, Nigeria
Correspondence Address:
Olufemi Adebayo Ige
Department of Anaesthesia, University of Ilorin, Ilorin
Nigeria
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/njgp.njgp_2_21
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Background: The use of preincision low-dose ketamine as a preemptive analgesic modality has been widely suggested. However, findings from previous studies have remained inconclusive. Materials and Methods: Eighty-two patients scheduled to have elective thyroidectomy under general anesthesia were recruited. The patients were randomly allocated into one of two groups, to receive either 0.5 mg/kg of ketamine intravenously or an equal volume of normal saline, 10 min before surgical incision. At the end of surgery, pain scores, time to first request for analgesic and total opioid requirement in 24 h postoperatively were recorded. Results: There was no significant difference in the postoperative pain scores, time to first requirement for analgesic, postoperative opioid consumption and satisfaction with analgesia between the two groups. The median pain scores at recovery, 2, 6, 12, and 24 h postoperatively for the ketamine and saline groups were not significantly different (P values 0.208, 0.185, 0.412, 0.590, and 0.854 respectively). The times to first request for analgesic were 86.00 ± 56.58 min in the ketamine group and 79.90 ± 68.05 min in the saline group (P = 0.357). The 24-h opioid (morphine) consumptions were 11.00 ± 3.16 mg in the ketamine group and 13.21 ± 5.87 mg in the control group (P = 0.275). Conclusion: This study concluded that the administration of preincision low-dose ketamine (0.5 mg/kg) did not produce a preemptive analgesic effect in patients who had an elective thyroidectomy.
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