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ORIGINAL ARTICLE
Year : 2021  |  Volume : 19  |  Issue : 1  |  Page : 11-15

Microbial isolates and sensitivity patterns among antenatal patients with asymptomatic bacteriuria in a tertiary hospital in north-central Nigeria


1 Department of Obstetrics and Gynecology, Federal Medical Centre, Keffi, Nigeria
2 Department of Microbiology, Federal Medical Centre, Keffi, Nigeria

Correspondence Address:
Gerald Tochukwu Igwemadu
Department of Obstetrics and Gynecology, Federal Medical Center, Keffi
Nigeria
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/NJGP.NJGP_16_20

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Introduction: Asymptomatic bacteriuria (ASB) in pregnancy is defined as the presence of at least 105 colony-forming units per milliliter of a bacteria species in clean-catch urine in the absence of obvious symptoms of urinary tract infection during pregnancy. It is associated with obstetric complications such as preeclampsia, pyelonephritis, preterm labor, low birth weight, and prematurity. Determining the microbial isolates and sensitivity patterns of ASB among pregnant women locally will aid the management of ASB in pregnancy and prevention of complications associated with it. Objective: The aim of the study was to determine the microbial isolates and sensitivity pattern among antenatal patients with ASB at the Federal Medical Center (FMC), Keffi, Nasarawa state. Materials and Methods: This is a cross-sectional study among pregnant women attending the antenatal clinic at the FMC, Keffi, with ASB. Clients who met the selection criteria were recruited for the study. A structured pro forma was administered, and midstream urine samples were collected and processed. Result was analyzed using the Statistical Package for the Social Sciences version 20. Chi-square at a significant level of 0.05 and confidence level of 95% was used to determine significance. Results: A total of 184 consented women presenting for their first antenatal visit were screened for ASB, of which 82 were positive for significant bacteriuria, giving a prevalence of 44.6%. The ages of the participants ranged from 18 to 43 with a mean age of 29.58 ± 5.42 years. The common uropathogens isolated were Staphylococcus aureus 43 (52.4%), Klebsiella spp. 14 (17.1%), and Escherichia coli 13 (15.9%). The isolates were most sensitive to amoxicillin-clavulanate (85.4%), nitrofurantoin (82.9%), and gentamicin (79.3). Conclusion: The prevalence of ASB among the study participants was high. S. aureus, Klebsiella spp., and E. coli were the predominant organisms cultured while most of the isolates were sensitive to amoxicillin-clavulanate, nitrofurantoin, and gentamicin.


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