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Year : 2020  |  Volume : 18  |  Issue : 1  |  Page : 22-26

Predonation iron and hematological status of whole blood donors in lagos, Nigeria: Impact on blood supply

1 Department of Haematology and Blood Transfusion , College of Medicine, University of Lagos, Lagos, Nigeria
2 Department of Chemical Pathology, College of Medicine, University of Lagos, Lagos, Nigeria
3 Department of Division of Epidemiology and Biostatistics, School of Public Health, University of Witwatersrand, Johannesburg, South Africa

Correspondence Address:
Sarah O John-Olabode
Department of Haematology and Blood Transfusion, College of Medicine, University of Lagos, Lagos State
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/NJGP.NJGP_8_19

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Context: Regular blood donations can engender iron depletion and its complications; reducing the prevalence of iron depletion among blood donors is a key strategy for optimizing donors' health. However, the factors impacting on iron deficiency among blood donors are not yet well characterized in our environment. Aim: The aim of this study is to determine predonation iron status and hematological profile among blood donors. Settings and Design: We conducted a comparative cross-sectional study of eligible blood donors at Lagos University Teaching Hospital. Consenting participants were consecutively recruited. Materials and Methods: Sociodemographic data were collected using an interviewer-administered questionnaire. Blood samples for estimation of ferritin, serum iron, total iron-binding capacity, and complete blood count were collected. Statistical Analysis Used: Statistical analysis was conducted using Stata version 14 software. Results: About three-fourths of the participants (n = 234, 74.8%) were first-time donors and one-fourth (n = 79, 25.2%) were frequent donors. Overall, 16 (5.1%) of the blood donors had depleted iron stores. There was a significant difference in the prevalence of iron depletion between first-time and regular donors (P < 0.01). Multivariable analysis showed that the odds of iron deficiency decreased by 58% for every g/dl increase in hemoglobin levels (odds ratio = 0.42, 95% confidence interval: 0.24–0.73, P = 0.002). Smokers had about 14-fold odds of having iron deficiency as compared to nonsmokers. Conclusion: Although current donation strategies to mitigate donation-related iron loss have resulted in a significant decline in the prevalence of iron deficiency in frequent blood donors, we are still a long way from keeping our iron-replete blood donors.

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